Summary
In this presentation Dr. Tracy gives a brief history of the development of markers of inflammation and discusses the ability of inflammatory markers to predict disease. Important issues in assay development and use are discussed, as well as future directions for inflammation measurement research.
Inflammation covers a broad range of molecular mechanisms, says Dr. Tracy, and various biomarkers are available or will be to assess different aspects.
Future directions for inflammation measurement research include combining biomarkers, using larger panels of markers for assessment of whole pathways, and using cell-based assays.
Copyright © 2004 MULTIWEBCAST "State-of-the-Art Webcast Services"
Learning objectives
After viewing this presentation the participant will be able to discuss:
- The history of markers of inflammation
- Data relating to the predictive value of inflammatory biomarkers
- Important issues in assay development and use
- Future directions for inflammation measurement research
Bibliographic references
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Paramo JA, Beloqui O, Roncal C, Benito A, Orbe J.Validation of plasma fibrinogen as a marker of carotid atherosclerosis in subjects free of clinical cardiovascular disease.Haematologica. 2004 Oct;89(10):1226-31.
Paul M. Ridker, MD; Nader Rifai, MD; Meir J. Stampfer, MD; Charles H. Hennekens, MD.Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men Circulation. 2000;101:1767.
Paul M. Ridker, M.D., Charles H. Hennekens, M.D., Julie E. Buring, Sc.D., and Nader Rifai, Ph.D.C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in WomenNEJM.2000;342:836-843.
Paul M. Ridker, M.D., Mary Cushman, M.D., Meir J. Stampfer, M.D., Russell P. Tracy, Ph.D., and Charles H. Hennekens, M.D. Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy MenNEJM.1997;336:973-979.
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